Diclofenac sodium, the active substance of Arnil has established itself in the leading group of non steroidal anti-rheumatics. Diclofenac sodium owes this place chiefly due to its marked anti-inflammatory and analgesic effects, its extremely high therapeutic index, and its favourable pharmacokinetic properties.

Anril reliably combats the pain and inflammation typical of all rheumatic diseases. At Brookes, we have given yet another plus point to this compound by giving it a unique dosage form, and thus, for the first time in Pakistan, diclofenac sodium is available in 75mg strength to take care of patients with severe pain and inflammation.

PRESENTATION:
ARNIL 75:
Round shaped, enteric coated, blue-coloured tablet.
ARNIL 50:
Triangular, enteric coated, cream coloured tablets.

COMPOSITION:
ARNIL 75:
Each enteric coated tablet contains:
Diclofenac sodium 75mg
ARNIL 50:
Each enteric coated tablet contains:
Diclofenac sodium 50mg.

PHARMACOKINETICS:
Diclofenac sodium is rapidly absorbed into the plasma with peak levels occurring at nearly two hours. It is extensively bound to plasma proteins. The elimination half-life is about 1.2 to 1.8 hours. Diclofenac penetrates rapidly into synovial fluid. Peak levels in the synovial fluid of patients with active rheumatoid arthritis and chronic joints effusion are achieved 2 to 4 hours following single or multiple dosing. Higher synovial fluid levels are sustained for up to 12 hours after single or multiple dose therapy.

INDICATION:
Arnil is indicated for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic juvenile arthritis and in other musculo-skeletal disorders including periarthritis, bursitis, tendinitis, sprains and strains. Arnil also controls pain and inflammation in acute gout, minor surgery and trueauma.

DOSAGE:
Arnil 75: 1 tablet B.I.D.
Arnil 50: 1 tablet B.I.D.
Or as directed by the Physician.

SIDE-EFFECTS:
Arnil (Diclofenac sodium) is generally very well tolerated. Patients may sometimes complain of mild headache, dizziness, nausea, diarrhoea, epigastric pain at the start of treatment which usually disappears within a few days with discontinuation of therapy. Skin-rash, peripheral oedema and slight increase in transaminase value has infrequently been reported. Rarely as with other NSAIDs, anaphylaxis, laryngeal spasm and bronchospasm has been reported.

CONTRA-INDICATION:
Sensitivity to Diclofenac, peptic ulceration, asthma, where patients are hypersensitive to aspirin or other prostaglandin synthetase inhibitors.

PRECAUTIONS:
As with other NSAIDs peiodic monitoring of liver enzymes, creatinine, blood count and urinalysis should be carried out. Avoid in patients with a history of peptic ulcer, haematemesis or in patients with severe hepatic or renal insufficiency.

PACK:
Arnil 75:
Blister pack of 2x10's
Arnil 50:
Blister pack of 2x10's