The terminal phase of the wound healing process is characterized by the formation of a tough, stable wound closure-the SCAR.

Contractubex Gel developed by MERZ+CO. specifically for the treatment of scars and keloids. Contractubex has achieved outstanding success in the local treatment of hyper-and hypo-trophic, movement -impeding and keloidal scars. Both old and recent scars become smoother and the tissue more functional, elastic, strong and less conspicuous.

PRESENTATION:
Light brown gel for external application.

COMPOSITION:
Each 100gm contains:
Extr. Cepae 10gm
Heparin Sodium 5000 I.U.
Allantoin 1 .g in water-solution, fat free hydrogel base-serol.

Contractubex Gel is a unique product because of its specific composition, wherein each ingredient has definite pharmacological effects.

EXTRACTUM CEPAE:
Is obtiained from Allium cepa which contains an array of substances that exert special effects on the skin. The content of sulphur containing peptides correlates with the glutathione content which plays a special part in cell metabolism. Together with the carbohy drates(glucose, fructose etc), these peptides also serve as substrates for cellular regeneration. The extract contains Vitamin A, known for its epithelium protective properties.

HEPARIN SODIUM:
Is isolated from tissue of animal origin (liver, lung heart) where it is to be found in the mastocytes. Local application induces regional heparinization. Thus when applied topically, heparin intensifies the fibrinolytic properties of the skin tissue and is thought to exert an inhibitory effect on fibroblast proliferation. Heparin increases tissue hydration and counteracts tissue induration. It also dilates the vessels and improves blood flow and thus the supply of essential substances. The anti-inflammatory properties of heparin guard against local inflammation-induced irritation.

ALLANTOIN:
Is an end product of purine metabolism in animal and plant tissues. It stimulates cellular proliferation and promotes the development of healthy cells, without giving rise to hyperplasia. These properties make allantoin ideally suited for the treatment of scars.
Allantoin promotes epithelialization and the formation of an elastic surface and counteracts the development of keloids. In older scars its main effect is to increase the water-binding capacity of the indurated tissue and to exert a keratolytic and softening activity. The pruritus frequently associated with scarring can be relieved by allantion.

SEROL:
Is a hydrophilic colloid with water-soluble protein components. It is extremely well tolerated, even with prolonged use.
It is non-greasy, colourless and odorless and can be used with or without a dressing, as it forms a protective film-like coating over the scars.

INDICATION:
DERMATOLOGY

• Scars from burns and scalds
  
• Acne and shingles (chicken pox) scars
  
• Scars following ulceration and acid burns
  
• Vaccination scars
  
• Keloids

SURGERY:

• Accidents and post-operative scars
  
• Scars resulting from plastic surgery, skin grafts
  
• Amputation scars

GYNAECOLOGY
Scars following caesarean section, radical hysterectomy, hypogastric incision associated with a tendency towards bulbous scar formation. Biopsy & Breast amputation scars.

ORTHOPEDICS
Dupuytren's contracture.
Post-amputation scars.

DOSAGE AND MODE OF APPLICATION
Contractubex Gel is slightly massaged into the skin or scar tissue, 3 to 4 times daily until complete penetration of the Gel. In case of hard, old scars Contractubex Gel may be allowed to take effect overnight under a dressing. According to the size of the existing scar or contracuture, treatment will be necessary for several weeks. Subsequent operation and transplants can often be avoided by the application of Contractubex Gel.

SIDE-EFFECTS:
None

CONTRA-INDICATIONS:
None

PACK:
20G tube in a carton

ADVANTAGES:
Epitheliogenic
Fibrinolytic
Relieves irritation
Inhibits inflammation
Stimulates regeneration
Inhibits pathological proliferation