A combination of ampicillin and cloxacillin. It belongs to PENICILLIN group and exhibits bactericidal action against a wide range of gram positive and gram negative bacteria including betalactamase producing staphylococci.

Most of the penicillins are inactivated by an enzyme penicillinase or Beta-Lactamase producing micro-organism; cloxacillin is effective against such micro-organisms.

PRESENTATION:
Di-Cillin is available as capsules (500mg & 250mg) and as Suspension for children in palatable lemon flavour.

COMPOSITION:
Each 500mg capsules contains:
250mg Ampicillin (asAmpicillin Trihydrate)
250mg Cloxacillin (as Cloxacillin Sodium)

Each 250mg capsule contains:
125mg Ampicillin (as Ampicillin Trihydrate)
125mg Cloxacillin (as Cloxacillin Sodium)

Each 5ml suspension contains:
125mg Ampicillin (as Ampicillin Trihydrate)
125mg Cloxacillin (as Cloxacillin Sodium)

PHARMACOKINETICS:
Ampicillin Trihydrate is relatively stable in gastric acid and is rapidly absorbed after oral administration. It diffuses readily into most body tissues and fluids. However, penetration into cerebrospinal fluid and brain occurs only with meningeal inflammation. Ampicillin is excreted largely unchanged in the urine. A high concentration is reached in bile and a part of it is excreted in the faeces.

Cloxacillin Sodium is also stable in gastric acid. After oral administration absorption is rapid but incomplete. Once absorbed it binds to serum protein mainly albumin. Cloxacillin is excreted unchanged in urine.
Food can interfere with the absorption of both Ampicillin & Cloxacillin. Peak plasma concentration is achieved about 2 hours following dose of 500mg by mouth.

INDICATION:
Di-Cillin is abroad spectrum antibiotic available for the treatment of infections caused by various gram-positive and gram-negative bacteria including penicillinase producing staphylococci. Di-Cillin is indicated in respiratory tract infections Ear, Nose and Throat infections.
Skin and soft tissue infections.
Gastro-intestinal infections.
Urinary tract infections.
Pelvic infections and Orthopaedic infections.

DOSAGE & ADMINISTRATION:
DI-CILLIN 500MG CAPSULES:

ADULTS:
1-2 capsules 4 to 6 hourly. The dose can be increased depending upon the severity of the conditions.

Di-Cillin 250mg capsules:
Children:
8-12 years
1-2 capsules 4 to 6 hourly

Di-Cillin Suspension:
Children:
up to 1 year
½ to 1 teaspoon, 4 to 6 hourly
2-7 years
1 to 2 teaspoon, 4 to 6 hourly

SIDE-EFFECT:
Di-Cillin is generally well tolerated at recommended dose. Like other penicillins, side effects are of mild and transitory nature.
Diarrhoea, nausea, vomiting have occurred and moderate elevation in serum SGOT has been noted. Severe pseudomembranous colitis has also been reported in some patients. Hypersensitivity reactions include erythematous and maculopapular rashes and urticaria. If such rashes occurs, discontinue the therapy.

CONTRA-INDICATIONS:
Previous hypersensitivity reactions to any of the penicillins.

PRECAUTIONS:
Prolonged use of antibiotics may give rise to over growth of non-susceptable organisms including fungi. If super infection occurs, appropriate measures should be taken. In prolonged therapy and particularly with high dosage schedules, periodic evaluation of the renal and haematopoietic systems is recommended.

PACK:
CAPSULE:
500mg (Green opaque capsule) 2x10's blister.
250mg (Blue opaque capsule) 2x10'x blister
SUSPENSION:
Bottle of 60ml in lemon flavour.