Dostin (Erdosteine) is the first disease modifying agent for respiratory tract diseases.

ACTION:
Dostin contains Erdosteine, which is a prodrug, has Anti-adhesive, Antibacterial, Antioxidant mucomodulatory and Anti-inflammatory effects. Dostin (Erdosteine) prevents bacterial adhesiveness to the mucosa by breaking disulphide bonds at fimbria of bacteria, thus exerts its antibacterial effect. Furthermore, Dostin has synergistic effect when it is administrated concomitantly with antibiotics. Dostin (Erdosteine) inhibits free oxygen radicals via thiol groups that it contains. Its potent antioxidant effect appears by increasing production of endogenous antioxidant such as glutathion (GSH), a compound that plays a key role in the cellular protection against the oxidative stress. Its antioxidant activity especially appears with protecting effect against the decreasing neutrophil chemotactic response, lipid peroxidation, inactivation of a-1 antitrypsin in patients smoking cigarette.Its mucolytic effect appears by breaking disulphide bonds of glycoproteins, which are included in composition of mucus. It improves expectoration by increasing mucociliary transport and modulating the mucus production and viscosity of the mucus.

PHARMACOKINETICS:
When taken orally the drug is absorbed from intestine and reached to the liver via hepatic circulation where it is converted into 3 active metabolite (I,II & III) that are eliminated via the kidneys.

• Absorption is not influenced by food. Maximum plasma concentration is reached afer 1.4 hours.
  
• It has the two blocked thiol groups. After absorption, it is metabolized to the active metabolite and thus, the previous blocked thiol groups become free.
  
• Elimination half life of erdosteine, metabolite I, II + III are 1.4, 1.5 and 2.9 hours respectively.
  
• Different pharmaceutical forms such as capsules and suspension are bioequivalent.