Amongst Quinolones the first choice is Quinox that's
because Quinox exhibits highly potent anti-bacterial
activity with low MIC.
Quinox (Ofloxacin) is anew oral and parentera anti-bacterial
agent for the clinical management of infections
by an entirely new group of anti-microbial - the
gyrase inhibitors, fluorinated quinolones.
This group is known for its superior bactericidal
activity, low incidence of side-effects, excellent
pharmacokinetic profile and there is no evidence
of plasmid-mediated resistance.
ACTION:
Quinox is a broad-spectrum bactericidal agent
which acts by inhibiting bacterial DNA gyrase,
the enzyme responsible for uncoating genetic material
as a pre-requisite to bacterial multiplication.
PHARMACOKINETICS:
Quinox
has excellent pharmacokinetic profile;
Bio
availability virtually 100%
Low-Protein
Binding 25%
Long-Half
life 6 hours
Tissue
Penetration is excellent in almost all body
tissues and fluids.
Sputum
concentration is higher than MICs of a variety
of causative pathogens.0
Excellent
penetration into prostatic fluid and tissue.
Quinox
concentration in kidney tissues is greater than
the MICs of pathogens responsible for infection.
Oblong
shape-white colored film coated tablet.
Colorless
sterile solution for intravenous use
in a glass bottle with green colored
flip-off plastic cap in addition to
rubber seal.
